BDBM50063166 (R)-3-(1H-Indol-3-yl)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-propionic acid::CHEMBL157704

SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI Key InChIKey=YLMQYIQDNAUTDZ-HSZRJFAPSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50063166   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063166((R)-3-(1H-Indol-3-yl)-2-(4'-methoxy-biphenyl-4-sul...)
Affinity DataIC50:  81nMAssay Description:Inhibitory activity against human gelatinase B (Matrix metalloproteinase-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063166((R)-3-(1H-Indol-3-yl)-2-(4'-methoxy-biphenyl-4-sul...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063166((R)-3-(1H-Indol-3-yl)-2-(4'-methoxy-biphenyl-4-sul...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dpa(Dnp)-Ala-Arg-NH2 as substrate measured up to 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50063166((R)-3-(1H-Indol-3-yl)-2-(4'-methoxy-biphenyl-4-sul...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory activity against human gelatinase A (matrix metalloproteinase-2 MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed