BDBM50065628 CHEMBL1368758::US9663511, Compound JTE013
SMILES CC(C)c1cc(NNC(=O)Nc2cc(Cl)nc(Cl)c2)nc2n(C)nc(C)c12
InChI Key InChIKey=RNSLRQNDXRSASX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50065628
Affinity DataIC50: 10nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of S1PR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR1 expressed in CHOK1 cell membranes pretreated for 30 mins followed by [32P]S1P addition measured...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR3 expressed in Chem1 cell membranes co-expressing Galpha15 pretreated for 30 mins followed by [32...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR2 expressed in Chem1 cell membranes co-expressing Galpha15 pretreated for 30 mins followed by [32...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human S1P2 receptorMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Universitaire Vaudois
Curated by ChEMBL
Universitaire Vaudois
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat S1P2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR5 expressed in commercial cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR1 expressed in commercial cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR3 expressed in commercial cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Washington University
Curated by ChEMBL
Washington University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR4 expressed in commercial cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR2 expressed in commercial cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKon: 0.161M-1s-1Assay Description:Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant measured for 60 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Antagonist activity at S1P2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 1.96E+3nMAssay Description:Binding affinity to S1PR2 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair