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Found 10 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 2' and Ligand = 'BDBM50065628'
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  11nMAssay Description:I. Master Stock SolutionUnless specified otherwise, the sample compounds were diluted in 100% anhydrous DMSO including all dilutions. The compounds w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at S1P2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human S1P2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at rat S1P2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  58nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR2 expressed in Chem1 cell membranes co-expressing Galpha15 pretreated for 30 mins followed by [32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  67nMAssay Description:Displacement of [32P]S1P from recombinant human S1PR2 expressed in commercial cell membranes incubated for 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataIC50:  69nMAssay Description:Inhibition of S1PR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataKon:  0.161M-1s-1Assay Description:Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant measured for 60 secs by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065628(CHEMBL1368758 | US9663511, Compound JTE013)
Affinity DataKd:  1.96E+3nMAssay Description:Binding affinity to S1PR2 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails PubMed