BDBM50069111 (2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid::2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid::CHEMBL40123

SMILES N[C@@H](C[C@H](CC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O

InChI Key InChIKey=LSXSDBGWRLZZIR-RDJZCZTQSA-N

Data  7 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50069111   

TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi:  6.10E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi:  1.80E+4nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50: >3.00E+5nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 5 by measuring ACPD (100 uM)-stimulated phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity of the compound against human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50:  1.80E+4nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 2 by measuring ACPD (3 uM) induced inhibitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50:  6.10E+3nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 3 by measuring ACPD (3 uM) induced inhibitio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50:  380nMAssay Description:Binding affinity against Ionotropic glutamate receptor using [3H]- CGS-19755 displacement from rat forebrain preparationsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50: >3.00E+5nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 8 by measuring L-AP4 (0.3 uM of forskolin) (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50: >3.00E+5nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 4 by measuring L-AP4 (3 uM) induced inhibiti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50: >3.00E+5nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human mGlu7a receptor by measuring L-AP4 (1000 uM of forskolin (15 microM)-stimula...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50: >1.00E+5nMAssay Description:Binding affinity against Ionotropic glutamate receptor using [3H]- CGS-19755 displacement from rat forebrain preparationsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataIC50: >3.00E+5nMAssay Description:Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 1 by measuring ACPD (100 uM)-stimulated phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed