BDBM50069799 CHEMBL3407579::US9187441, 7M

SMILES CC(C)(C)NC(=O)C(N(Cc1cc(F)c(F)c(F)c1)C=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O

InChI Key

Data  4 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50069799   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Pittsburgh

US Patent
LigandPNGBDBM50069799(CHEMBL3407579 | US9187441, 7M)
Affinity DataKi:  0.130nM ΔG°:  -13.3kcal/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Pittsburgh

US Patent
LigandPNGBDBM50069799(CHEMBL3407579 | US9187441, 7M)
Affinity DataKi:  130nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Pittsburgh

US Patent
LigandPNGBDBM50069799(CHEMBL3407579 | US9187441, 7M)
Affinity DataKi:  400nMAssay Description:Displacement of fluorescent F4 peptide from MDM2 (1 to 125 residues) (unknown origin) expressed in Escherichia coli by fluorescence polarization assa...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Pittsburgh

US Patent
LigandPNGBDBM50069799(CHEMBL3407579 | US9187441, 7M)
Affinity DataKi:  800nMAssay Description:Displacement of 5-FAM labeled PMDM6-F from GST-tagged human recombinant MDM2 (1 to 118 residues) expressed in Escherichia coli incubated for 0.5 hrs ...More data for this Ligand-Target Pair