BDBM50075576 CHEMBL3415554
SMILES CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1
InChI Key InChIKey=IIDTUADQWHMXCU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50075576
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£
Curated by ChEMBL
Umr Cnrs-Universit£
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£
Curated by ChEMBL
Umr Cnrs-Universit£
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£
Curated by ChEMBL
Umr Cnrs-Universit£
Curated by ChEMBL
Affinity DataIC50: <800nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£
Curated by ChEMBL
Umr Cnrs-Universit£
Curated by ChEMBL
Affinity DataKd: 100nMAssay Description:Binding affinity to wild type B-Raf (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£
Curated by ChEMBL
Umr Cnrs-Universit£
Curated by ChEMBL
Affinity DataEC50: <500nMAssay Description:Activation of tumorigenic wild type B-Raf in human IPC-298 cells with Ras mutation assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£
Curated by ChEMBL
Umr Cnrs-Universit£
Curated by ChEMBL
Affinity DataKd: 140nMAssay Description:Binding affinity to B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair