BDBM50075576 CHEMBL3415554

SMILES CCCS(=O)(=O)Nc1cc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c(F)c1

InChI Key InChIKey=IIDTUADQWHMXCU-UHFFFAOYSA-N

Data  3 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50075576   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataIC50:  160nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataIC50:  13nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataIC50: <800nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataKd:  100nMAssay Description:Binding affinity to wild type B-Raf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataEC50: <500nMAssay Description:Activation of tumorigenic wild type B-Raf in human IPC-298 cells with Ras mutation assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataKd:  140nMAssay Description:Binding affinity to B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed