BDBM50107283 AAT-007::CJ-023::Grapiprant::MR-10A7::RQ-00000007::RQ-7
SMILES CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
InChI Key InChIKey=HZVLFTCYCLXTGV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50107283
Affinity DataKi: 13nMAssay Description:Displacement of [3H]PGE from human EP4 receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Antagonist activity at rat recombinant EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Antagonist activity at dog recombinant EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 448nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 449nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human platelet TP receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human EP1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human FP receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human IP receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human EP2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Antagonist activity at human EP3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+3nMAssay Description:Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretrea...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...More data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+3nMAssay Description:Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha release pretreated for 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 689nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
Affinity DataIC50: 1.61E+3nMAssay Description:Antagonist activity at EP4 receptor in LPS-stimulated human whole blood assessed as inhibition of PGE2-induced TNF-alpha reduction preincubated for 3...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scinti...More data for this Ligand-Target Pair