BDBM50110681 CHEMBL430266::Calyculin-A
SMILES COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)c1nc(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C(\C)=C\C=C\C(\C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)co1)N(C)C
InChI Key InChIKey=FKAWLXNLHHIHLA-YCBIHMBMSA-N
Data 20 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50110681
TargetSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uMMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Concentration required to inhibit the action of protein phosphatase 2AMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against Protein phosphatase 1 was determined; 0.5-1.0More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 1 (PP1)More data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)More data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild typeMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in N124DMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220VMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272FMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R221SMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275RMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Gallus gallus)
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127SMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D208AMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in R96AMore data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: >500nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in H248NMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uMMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Tested for inhibition against purified catalytic subunit of protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair