BDBM50121180 5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2'(1'H)-one::CHEMBL324115

SMILES Clc1cccc(c1)-c1ccc2NC(=O)C3(CCCCC3)c2c1

InChI Key InChIKey=XVGXCHRWZFIARX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50121180   

TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121180(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Affinity DataIC50:  56nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121180(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Affinity DataIC50:  477nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121180(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Affinity DataIC50:  56nMAssay Description:Inhibitory activity against progesterone receptor induced alkaline phosphatase activity in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed