BDBM50124597 5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL267231

SMILES CC1=CC(C)(C)Nc2ccc-3c(C(CC=C)Oc4cccc(OC(F)F)c-34)c12

InChI Key InChIKey=VKNDUDKNPQIQIQ-UHFFFAOYSA-N

Data  3 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50124597   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataKi:  2.20nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataKi:  96nMAssay Description:Binding affinity towards testosterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataKi:  349nMAssay Description:Displacement of [3H]-progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataEC50:  18nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataEC50:  85nMAssay Description:Inhibition of conconavalin A stimulated rat splenocyte proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataEC50:  563nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124597(5-Allyl-10-difluoromethoxy-2,2,4-trimethyl-2,5-dih...)
Affinity DataEC50:  35nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed