BDBM50128581 Biphenyl-3-yl-carbamic acid cyclohexyl ester::CHEMBL77767::URB602::biphenyl-3-ylcarbamic acid cyclohexyl ester::cyclohexyl biphenyl-3-ylcarbamate

SMILES O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1

InChI Key InChIKey=HHVUFQYJOSFTEH-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50128581   

TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University of California Irvine

LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  2.23E+5nMpH: 8.0Assay Description:The measurement of the ability of URB602 compound to inhibit MGL activity. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50: >3.00E+4nMAssay Description:Fatty acid amide hydrolase inhibitory activity in rat brain membrane using [3H]-anandamide as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  5.65E+3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University of California Irvine

LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of MAGL in Wistar rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of MAGL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University of California Irvine

LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of MAGL from Wistar rat brain using 2-monooleoyl[1,2,3-H]glycerol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University of California Irvine

LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of Wistar rat MAGL using 2-monooleoyl[1,2,3-3H]glycerol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of recombinant human MAGL using 7-HRA as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of MAGL in mouse B16-F10 cells using 7-HRA as substrate preincubated for 60 mins followed by substrate addition measured every 2.5 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Louvain Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50128581(Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHE...)
Affinity DataIC50:  5.75E+3nMAssay Description:Inhibition of human recombinant FAAH-maltose binding proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed