BDBM50135142 6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL424135

SMILES COc1ccc(OC)c(NCc2cnc3nc(N)nc(N)c3c2)c1

InChI Key InChIKey=YSSYHMDWUMVMEA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50135142   

TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135142(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[2,3-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of dihydrofolate reductase from rat liver.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135142(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[2,3-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of rat liver DHFR assessed as reduction in consumption of NADPH using DHFA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135142(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[2,3-...)
Affinity DataIC50:  450nMAssay Description:Inhibition of dihydrofolate reductase from toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50135142(6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[2,3-...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of dihydrofolate reductase from pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed