BDBM50168434 CHEMBL3805738

SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(F)c2c(=O)n1-c1cc(F)cc(F)c1

InChI Key InChIKey=YTPMIHHBQWNYIV-VIFPVBQESA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50168434   

LigandPNGBDBM50168434(CHEMBL3805738)
Affinity DataIC50:  2.20nMAssay Description:Inhibition human full length PI3Kdelta catalytic subunit/p85alpha assessed as formation of PIP3 after 30 mins by europium labeled GRP-based TR-FRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168434(CHEMBL3805738)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human full length PI3K p110delta/p85alpha using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168434(CHEMBL3805738)
Affinity DataEC50:  1nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as basophil degranulation by measuring CD63 surface expression on CCR3 positive cells after 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed