BDBM50193796 3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-yl]-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-2-one::CHEMBL218570

SMILES CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)c2nnn[nH]2)C1=O

InChI Key InChIKey=JIPIIKUPMSVLEL-WFEZEDJFSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50193796   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193796(3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-y...)
Affinity DataIC50:  430nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193796(3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-y...)
Affinity DataIC50:  630nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193796(3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-y...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193796(3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-y...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50193796(3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-y...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed