BDBM50220291 1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiperidin-2-yl)cyclopropyl 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylate::CHEMBL236184

SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCN(CC1)C(C)(C)CO

InChI Key InChIKey=UTPYURSIXIVBEJ-IFMALSPDSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50220291   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220291(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of gamma-secretase assessed as reduction of cell Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220291(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50220291(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50220291(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CYP3A4 preincubated before 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50220291(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed