BDBM50241114 3-(2,4-Difluoro-phenylamino)-6H-dibenzo[b,e]oxepin-11-one::3-(2,4-difluoro-phenylamino)-6,11-dihydro-dibenzo[b,e]oxepin-11-one::CHEMBL376855

SMILES Fc1ccc(Nc2ccc3c(OCc4ccccc4C3=O)c2)c(F)c1

InChI Key InChIKey=JELAHDQPMBHMAI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50241114   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50241114(3-(2,4-Difluoro-phenylamino)-6H-dibenzo[b,e]oxepin...)
Affinity DataIC50:  240nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) by cell-free enzyme immunosorbent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50241114(3-(2,4-Difluoro-phenylamino)-6H-dibenzo[b,e]oxepin...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50241114(3-(2,4-Difluoro-phenylamino)-6H-dibenzo[b,e]oxepin...)
Affinity DataIC50:  239nMAssay Description:Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50241114(3-(2,4-Difluoro-phenylamino)-6H-dibenzo[b,e]oxepin...)
Affinity DataIC50:  239nMAssay Description:Inhibition of p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed