BDBM50241179 (S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole (Levamisole)::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(Levamisole)::6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(tetramisole)::CHEMBL1454::LEVAMISOLE::LEVAMISOLE HYDROCHLORIDE::TCMDC-125847::cid_68628::levamisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole::tetramisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole

SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1

InChI Key InChIKey=HLFSDGLLUJUHTE-SNVBAGLBSA-N

Data  4 KI  22 IC50  1 EC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50241179   

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bos taurus (Cattle))
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataKi:  1.81E+3nMAssay Description:Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of TNSALP (unknown origin)More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataKi:  1.60E+4nMpH: 9.8Assay Description:Inhibition of human tissue non-specific alkaline phosphatase at pH 9.8More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataKi:  9.30E+4nMAssay Description:Inhibition of recombinant TNAPMore data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bos taurus (Cattle))
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Universit£ de Lyon

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMpH: 10.4Assay Description:Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, placental type(Homo sapiens (Human))
Universit£ de Lyon

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMpH: 10.4Assay Description:Inhibition of human placental alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by subst...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, placental type(Homo sapiens (Human))
Universit£ de Lyon

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMpH: 7.8Assay Description:Inhibition of human placental alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by substr...More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Bos taurus (Cattle))
Universit£ de Lyon

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMpH: 7.8Assay Description:Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...More data for this Ligand-Target Pair
TargetPhospholipase A-2-activating protein(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PLAP by analogous luminescence assayMore data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TNAP by analogous luminescence assayMore data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of IAP by analogous luminescence assayMore data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of intestinal alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incuba...More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of intestinal alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubat...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, placental type(Homo sapiens (Human))
Universit£ de Lyon

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 10.4 incubat...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, placental type(Homo sapiens (Human))
Universit£ de Lyon

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of placental alkaline phosphatase (unknown origin) assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 incubate...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bos taurus (Cattle))
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human IAP using CDP-star as substrate pretreated for 10 mins followed by substrate addition measured after 10 mins by spectrophotometri...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human TNAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by su...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bos taurus (Cattle))
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 2.02E+4nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bos taurus (Cattle))
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 1.92E+4nMpH: 9.8 T: 2°CAssay Description:Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...More data for this Ligand-Target Pair
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by sub...More data for this Ligand-Target Pair
TargetCorticotropin-releasing factor-binding protein(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataEC50: >5.30E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Bos taurus (Cattle))
Forman Christian College (A Chartered University)

Curated by ChEMBL
LigandPNGBDBM50241179((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Affinity DataIC50: 1.92E+4nMpH: 9.8 T: 2°CAssay Description:The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...More data for this Ligand-Target Pair