BDBM50241293 (5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester::ALBENDAZOLE::Albenza::CHEMBL1483::SK&F-62979::methyl 5-(propylthio)-1H-benzo[d]imidazol-2-ylcarbamate::methyl 6-(propylthio)-1H-benzo[d]imidazol-2-ylcarbamate

SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1

InChI Key InChIKey=HXHWSAZORRCQMX-UHFFFAOYSA-N

Data  11 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50241293   

TargetMethionine aminopeptidase(Escherichia coli (strain K12))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Co2+ loaded MetAP expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50241293((5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic ...)
Show SMILES CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1
Show InChI InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair