BDBM50250947 CHEMBL4092976

SMILES CCc1c(cnc(N)c1-c1ccc(O)cc1)-c1ccc(nc1)C(=O)NC

InChI Key InChIKey=UCYSSYGGXOFJKK-UHFFFAOYSA-N

Data  5 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50250947   

TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataEC50:  2.58E+3nMAssay Description:Inhibition of USP7 in human SJSA cells assessed as increase in ubiquitinated MDM2 level after 16 hrs in presence of MG132 by MSD assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of native full length C-terminal USP7 (unknown origin) using ubiquitin-Rho110 as substrate pre-incubated for 1 hr followed by substrate ad...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human USP7 using ubiquitin-Rho as substrate incubated for 1 hrsMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged N-terminal GST-tagged full length USP7 using di-ubiquitin as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of human USP7 using UbA10 as substrate incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50250947(CHEMBL4092976)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of recombinant USP7 (unknown origin) by mass spectrometry based activity assayMore data for this Ligand-Target Pair