BDBM50252049 (1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid::(2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid::CHEMBL482081

SMILES N[C@@H](C[C@@H](CCC(O)=O)C(O)=O)C(O)=O

InChI Key InChIKey=YSWVADAJIFHTLV-UHNVWZDZSA-N

Data  3 KI  6 IC50  15 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50252049   

TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataKi: >3.00E+6nMAssay Description:Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataKi: >3.00E+6nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50:  3.48E+5nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50:  1.66E+3nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50:  1.63E+3nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in HEK293 cells by [35S]GTP-gamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu5 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50:  3.42E+4nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu7 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu8 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50:  1.20E+5nMAssay Description:Agonist activity at rat mGlu2 receptor by FRET based mGlu sensor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu3 receptor by FRET based mGlu sensor assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of human EAAT1 assessed as [3H]Asp uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of human EAAT2 assessed as [3H]Asp uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of human EAAT3 assessed as [3H]Asp uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataIC50:  3.00E+6nMAssay Description:Inhibition of glutamate-induced depolarization in human human EAAT3 expressed in HEK293 cells by FMP assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataIC50:  3.00E+6nMAssay Description:Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataIC50:  3.00E+6nMAssay Description:Inhibition of glutamate-induced depolarization in human human EAAT2 expressed in HEK293 cells by FMP assayChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed