BDBM50252739 CHEMBL494072::N-Cyclopropyl-4-methyl-3-(2-((2-(4-morpholinyl)ethyl)amino)-6-quinazolinyl)benzamide::N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide

SMILES Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)NC1CC1

InChI Key InChIKey=MNEXDVSJIUQQRH-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50252739   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50:  10.5nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50:  122nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50:  629nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50:  788nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50252739(CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-...)
Affinity DataIC50:  162nMAssay Description:Inhibition of cKit (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed