BDBM50264809 2-((4-phenoxyphenylsulfonyl)methyl)thiirane::CHEMBL483857::Thiirane (deuterium), 1-d2::Thiirane, 1::US10357546, SB-3CT

SMILES O=S(=O)(CC1CS1)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=LSONWRHLFZYHIN-UHFFFAOYSA-N

Data  35 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50264809   

TargetStromelysin-1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain by substrate hydrolysis based fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  1.50E+4nMAssay Description:Competitive inhibition of human MMP3 using fluorogenic substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50264809(2-((4-phenoxyphenylsulfonyl)methyl)thiirane | CHEM...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed