BDBM50281849 CHEMBL4175305

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2cnc(O[C@@H](C)c3ccccc3)c(Cl)c2)cc1

InChI Key InChIKey=VMHNMQCWPLURSW-INIZCTEOSA-N

Data  7 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50281849   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50:  255nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISAMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50:  17nMAssay Description:Inverse agonist activity at human GAL4-DBD fused RORgammat LBD expressed in human Jurkat cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataKd:  36nMAssay Description:Binding affinity to RORgammat (unknown origin) by reporter displacement assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50:  0.600nMAssay Description:Inverse agonist activity at human His6-tagged RORgammat LBD (264 to 518 residues) assessed as reduction in biotinylated RIP140 co-activator recruitme...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50:  14nMAssay Description:Inverse agonist activity at human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal ant...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50:  23nMAssay Description:Inverse agonist activity at RORgammat in human PBMC-derived CD4-positive Th-17 polarized cells assessed as reduction in IL4/anti-IFN-gamma antibody-s...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataKd:  8nMAssay Description:Binding affinity to RORgammat (unknown origin) by ITCMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50:  4.11E+3nMAssay Description:Inverse agonist activity at human GAL4-DBD fused RORbeta LBD expressed in human Jurkat cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281849(CHEMBL4175305)
Affinity DataIC50: >1.00E+4nMAssay Description:Inverse agonist activity at human GAL4-DBD fused RORalpha LBD expressed in human Jurkat cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed