BDBM50294743 CHEMBL550035::[3-(3-Benzyl-8-chlorocinnolin-4-yl)phenyl][2-chloro-3-(trifluoromethyl)benzyl]amine

SMILES FC(F)(F)c1cccc(CNc2cccc(c2)-c2c(Cc3ccccc3)nnc3c(Cl)cccc23)c1Cl

InChI Key InChIKey=XHUGCOUNHPKMDJ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50294743   

TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294743(CHEMBL550035 | [3-(3-Benzyl-8-chlorocinnolin-4-yl)...)
Affinity DataEC50:  3.63E+3nMAssay Description:Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiva...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294743(CHEMBL550035 | [3-(3-Benzyl-8-chlorocinnolin-4-yl)...)
Affinity DataEC50:  1.11E+4nMAssay Description:Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiv...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294743(CHEMBL550035 | [3-(3-Benzyl-8-chlorocinnolin-4-yl)...)
Affinity DataIC50:  4.00E+4nMAssay Description:Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294743(CHEMBL550035 | [3-(3-Benzyl-8-chlorocinnolin-4-yl)...)
Affinity DataIC50:  1.12E+6nMAssay Description:Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRalpha ligand binding domain (197-447) expressed in Escherichia ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed