BDBM50306425 2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL605756

SMILES Cc1cccc2C(CC(O)=O)CC3(CCN(CC3)C(=O)NC3C4CC5CC(C4)CC3C5)c12

InChI Key InChIKey=LYHDMCHAMJFTNL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306425   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306425(2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dih...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306425(2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dih...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306425(2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dih...)
Affinity DataIC50:  18.3nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed