BDBM50327790 (R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)propan-1-one::CHEMBL1257282

SMILES Cc1c[nH]c2ncnc(N3CCN(CC3)C(=O)[C@H](N)Cc3ccc(F)cc3)c12

InChI Key InChIKey=NROLMFHMWLAKRA-MRXNPFEDSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327790   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327790((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)
Affinity DataIC50:  3nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327790((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Akt in human LNCaP cell assessed as inhibition of PRAS40 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327790((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline-rich AKT1 substrate 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327790((R)-2-amino-3-(4-fluorophenyl)-1-(4-(5-methyl-7H-p...)
Affinity DataIC50:  160nMAssay Description:Inhibition of PRAS40 phosphorylation at Thr246 in human LNCaP cells after 1.5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed