BDBM50329962 CHEMBL404696::N-((S)-1-(2-(1-((3R,4S)-1-tert-butyl-3-(2,4-difluorophenyl)pyrrolidine-4-carbonyl)piperidin-4-yl)-5-chlorophenyl)propyl)acetamide::N-((S)-1-(2-(1-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperidin-4-yl)-5-chlorophenyl)propyl)acetamide

SMILES CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C

InChI Key InChIKey=GQLKTRKRMSMQCE-GKRYNVPLSA-N

Data  3 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50329962   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329962(CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-buty...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human MC4R expressed in CHO cells assessed as increase of alpha-MSH-stimulated cAMP release pretreated for 10 mins before alpha-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329962(CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-buty...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human MC4R expressed in CHO cells assessed as cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329962(CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-buty...)
Affinity DataIC50:  70nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329962(CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-buty...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329962(CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-buty...)
Affinity DataIC50:  70nMAssay Description:Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50329962(CHEMBL404696 | N-((S)-1-(2-(1-((3R,4S)-1-tert-buty...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed