BDBM50341271 (Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-ylidene)methyl)phenoxy)acetate::CHEMBL1765901

SMILES COC(=O)COc1ccc(\C=C2/SC(=NC2=O)c2ccc(C)cc2)cc1

InChI Key InChIKey=CYHJKSMJJUKKSB-BOPFTXTBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341271   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341271((Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-y...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341271((Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-y...)
Affinity DataIC50:  190nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341271((Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-y...)
Affinity DataIC50:  190nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50341271((Z)-Methyl-2-(4-((4-oxo-2-(p-tolyl)-4H-thiazol-5-y...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed