BDBM50342457 (S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)(cyclobutyl)methanone::CHEMBL1771673

SMILES Clc1cccc(c1)-c1noc(n1)[C@@H]1CCCCN1C(=O)C1CCC1

InChI Key InChIKey=INTBVGDNRFKKFQ-HNNXBMFYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50342457   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataKi:  204nMAssay Description:Binding affinity to human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataIC50:  900nMAssay Description:Negative allosteric modulator activity at mGluR5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataIC50:  1.17E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed