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Found 3 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50342457'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataKi:  204nMAssay Description:Binding affinity to human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataIC50:  900nMAssay Description:Negative allosteric modulator activity at mGluR5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342457((S)-(2-(3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)pi...)
Affinity DataIC50:  1.17E+3nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed