BDBM50343624 5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphinan-3-yl-17-((-)-N-cyclobutylmethyl-14-hydroxyl-mophinan-3-yl)decanedioate::CHEMBL1774950

SMILES O[C@]12CCC(=O)[C@@H]3Oc4c5c(C[C@H]1N(CC=C)CC[C@@]235)ccc4OC(=O)CCCCCCCCC(=O)Oc1ccc2C[C@H]3N(CC4CCC4)CC[C@@]4(CCCC[C@@]34O)c2c1

InChI Key InChIKey=ZBRHLKCYFJFMJO-XYIWGVFMSA-N

Data  3 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50343624   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]U69563 from human kappa-opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human mu-opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataIC50:  34nMAssay Description:Antagonist activity at human mu-opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding after 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human kappa-opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50343624(5alpha-17-Allyl-14-hydroxy-6-oxo-4,5-epoxymorphina...)
Affinity DataIC50:  49nMAssay Description:Antagonist activity at human kappa-opioid receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTPgammaS binding after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed