BDBM50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147
SMILES N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
InChI Key InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50355501
Affinity DataEC50: 12nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins prior to EPO-induction measur...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins prior to IL6-induction measur...More data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as inhibition of STAT3 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Mus musculus)
Gwangju Institute Of Science And Technology (Gist)
Curated by ChEMBL
Gwangju Institute Of Science And Technology (Gist)
Curated by ChEMBL
Affinity DataEC50: 186nMAssay Description:Inhibition of JAK2 V617F mutant expressed in mouse BaF3 cells cells assessed as reduction in cell viabilityMore data for this Ligand-Target Pair
Affinity DataEC50: 3.80E+3nMAssay Description:Stabilization of human JAK2 KD expressed in Expi293F (HEK293F) cells assessed as increase in JAK2 protein levels incubated for 3 mins by isothermal d...More data for this Ligand-Target Pair