BDBM50359199 CHEMBL1923294
SMILES CN1CC(N)=NC(C)(C1=O)c1cccc(NC(=O)c2ccc(cn2)C#N)c1
InChI Key InChIKey=MFNPKKFGRAJHQS-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50359199
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics
Curated by ChEMBL
Research Informatics & Integrative Genomics
Curated by ChEMBL
Affinity DataIC50: 813nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics
Curated by ChEMBL
Research Informatics & Integrative Genomics
Curated by ChEMBL
Affinity DataIC50: 186nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics
Curated by ChEMBL
Research Informatics & Integrative Genomics
Curated by ChEMBL
Affinity DataIC50: 151nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair