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Found 3 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50359199'
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359199(CHEMBL1923294)
Affinity DataIC50:  151nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359199(CHEMBL1923294)
Affinity DataIC50:  186nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359199(CHEMBL1923294)
Affinity DataIC50:  813nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed