BDBM50361591 CHEMBL1939678::US9162979, 1-II

SMILES Cc1c(CC(=O)OCCO)cc(-c2ccc(cc2)S(C)(=O)=O)n1-c1ccccc1

InChI Key InChIKey=PORFXTNULPJUBW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50361591   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Rottapharm Biotech

US Patent
LigandPNGBDBM50361591(CHEMBL1939678 | US9162979, 1-II)
Affinity DataIC50:  27nMT: 2°CAssay Description:The murine monocyte/macrophage cell line J774 is grown in Dulbecco's modified Eagle's medium (DMEM), enriched with glutamine (2 mM), HEPES (25 mM), p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50361591(CHEMBL1939678 | US9162979, 1-II)
Affinity DataIC50:  96nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Mus musculus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50361591(CHEMBL1939678 | US9162979, 1-II)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells incubated for 15 mins prior to arachidonic acid-challeng...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed