BDBM50364485 CHEMBL1950720

SMILES CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CC[C@H]2CCN(CCc3ccccc3)C[C@@H]12

InChI Key InChIKey=HCSMRSHIIKPNAK-LSAVBLLPSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50364485   

TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at GST-tagged BIR3 domain of XIAP using AbuRPFK-5FAM after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataKd:  900nMAssay Description:Binding affinity to GST-tagged BIR3 domain of XIAP by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataIC50:  27nMAssay Description:Inhibition of cIAP1 BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed