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Found 3 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase XIAP' and Ligand = 'BDBM50364485'
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at GST-tagged BIR3 domain of XIAP using AbuRPFK-5FAM after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50364485(CHEMBL1950720)
Affinity DataKd:  900nMAssay Description:Binding affinity to GST-tagged BIR3 domain of XIAP by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed