BindingDB BDBM50366824 Avelox::MOXIFLOXACIN::Moxifl-oxacin

BDBM50366824 Avelox::MOXIFLOXACIN::Moxifl-oxacin

SMILES COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1

InChI Key InChIKey=FABPRXSRWADJSP-MEDUHNTESA-N

Data 1 KI 44 IC50

PDB links: 7 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50366824

Replicase polyprotein 1ab(2019-nCoV)
Michigan State University

BDBM50366824(Avelox | MOXIFLOXACIN | Moxifl-oxacin)

Ki: 2.49E+5nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Purchase ChEBI
DrugBank MCE
KEGG MMDB PC cid PC sid PDB Similars

Details Article PubMed

Filter my 45 hits

Targets 14▿
- Potassium voltage-gated channel subfamily H member 2 12
- DNA gyrase subunit B 10
- DNA gyrase subunit A/B 5
- DNA gyrase subunit A 4
- Potassium voltage-gated channel subfamily E/KQT member 1 2
- Voltage-dependent L-type calcium channel subunit alpha-1C 2
- Bile salt export pump 2
- Sodium channel protein type 5 subunit alpha 2
- ATP-binding cassette sub-family C member 3 1
- Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- Replicase polyprotein 1ab 1
- Polyphenol oxidase 2 1
- ...
Publications 30▿
- J Pharmacol Toxicol Methods 70: 246-54 (2014) 7
- Toxicol Sci 136: 216-41 (2013) 4
- J Med Chem 54: 3268-82 (2011) 2
- J Med Chem 65: 6903-6925 (2022) 2
- Antimicrob Agents Chemother 52: 2909-14 (2008) 2
- Antimicrob Agents Chemother 51: 2445-53 (2007) 2
- Bioorg Med Chem 17: 6879-89 (2009) 2
- J Med Chem 64: 6329-6357 (2021) 1
- Bioorg Med Chem Lett 15: 1737-41 (2005) 1
- Bioorg Med Chem 23: 2062-78 (2015) 1
- Bioorg Med Chem Lett 15: 2886-90 (2005) 1
- Eur J Med Chem 46: 618-30 (2011) 1
- Chem Biol Drug Des 86: 918-25 (2015) 1
- Eur J Med Chem 180: 648-655 (2019) 1
- J Med Chem 54: 3418-25 (2011) 1
- Bioorg Med Chem 16: 6252-60 (2008) 1
- Eur J Med Chem 103: 1-16 (2015) 1
- J Med Chem 45: 3844-53 (2002) 1
- Eur J Med Chem 44: 1926-32 (2009) 1
- J Med Chem 50: 199-210 (2007) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- Bioorg Med Chem 22: 4924-34 (2014) 1
- Bioorg Med Chem 21: 948-56 (2013) 1
- Bioorg Med Chem 24: 877-85 (2016) 1
- Sci Rep 3: (2013) 1
- Bioorg Med Chem Lett 23: 3848-51 (2013) 1
- Bioorg Med Chem 24: 42-52 (2016) 1
- J Med Chem 64: 16922-16955 (2021) 1
- J Appl Toxicol 32: 858-66 (2012) 1
- Bioorg Med Chem Lett 13: 2773-5 (2003) 1
Institutions 24▿
- University Of Oxford 7
- Achillion Pharmaceuticals 6
- Amgen 4
- Universit£ 3
- Birla Institute Of Technology 2
- Daiichi Sankyo 2
- University Of Cape Town 2
- Institute Of Technology & Science-Pilani 2
- Birla Institute of Technology 1
- Takeda Pharmaceutical 1
- Chantest 1
- Jagiellonian University 1
- Gedeon Richter 1
- Reverse Proteomics Research Institute 1
- Medical School Of Nanjing University 1
- Novartis Institutes For Biomedical Research 1
- University Of Bologna 1
- Tcg Lifesciences 1
- Astrazeneca 1
- Johnson & Johnson Pharmaceutical Research & Development 1
- F. Hoffmann-La Roche 1
- Michigan State University 1
- Casmedchem Laboratory 1
- Birla Institute Of Technology & Science-Pilani 1
Affinity: 1.2 to 1.3E+6 nM▿
- Ki 1
- IC50 44
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1