BDBM50392138 CHEMBL2152768

SMILES CC(C)(O)C1CCN(Cc2ccc3nc(nc(N4CCOCC4)c3n2)-c2c(F)ccc3[nH]ccc23)CC1

InChI Key InChIKey=ONEJEIKQLAZPNN-UHFFFAOYSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50392138   

LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  41nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as inhibition of CD69 production in B lymphocyte by immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PI3K p110delta using PIP2 as substrate assessed as PIP3 formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  794nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  40nMAssay Description:Inhibition of PI3Kdelta-mediated AKT phosphorylation in B cells in presence of human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Park Nottingham

Curated by ChEMBL
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50392138(CHEMBL2152768)
Affinity DataIC50:  41nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as upregulation of CD69More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed