BDBM50396483 PLX-4032::RG 7204::Ro 5185426::US10570155, Vemurafenib::US11332479, Compound Vemurafenib::US11492357, Control::US9388165, Reference, Vemurafenib (PLX-4032)::USRE47451, PLX-4032, Roche::VEMURAFENIB

SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F

InChI Key InChIKey=GPXBXXGIAQBQNI-UHFFFAOYSA-N

Data  83 IC50  6 Kd  8 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50396483   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataIC50:  111nMAssay Description:ormula (I) bis-hydrochloride salt prepared in Example 2 (hereinafter referred to as “Compound⋅2HCl”) was tested for inhibitory activity against...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataIC50:  107nMAssay Description:ormula (I) bis-hydrochloride salt prepared in Example 2 (hereinafter referred to as “Compound⋅2HCl”) was tested for inhibitory activity against...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D](Homo sapiens (Human))
Hanmi Pharm.

US Patent
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataIC50:  138nMAssay Description:ormula (I) bis-hydrochloride salt prepared in Example 2 (hereinafter referred to as “Compound⋅2HCl”) was tested for inhibitory activity against...More data for this Ligand-Target Pair
In DepthDetails US Patent