BDBM50400312 CHEMBL2181330

SMILES C(CN1CCCC1)Oc1ccc2Nc3nccc(n3)-c3cccc(COCC=CCOCc1c2)c3

InChI Key InChIKey=HWXVIOGONBBTBY-UHFFFAOYSA-N

Data  10 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50400312   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50:  520nMAssay Description:Inhibition of recombinant JAK3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibition of recombinant JAK1 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant JAK2 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as decrease in formation of 4-hydroxymephenytoin from mephenytoin substrate after 60 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant TYK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as decrease in formation of resorufin from ethoxyresorufin substrate after 5 mins by LC-MS/MSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as decrease in formation of dextrorphan from dextromethorphan substrate after 30 mins by LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as decrease in formation of 1-hydroxymidazolam from midazolam substrate after 5 mins by LC-MS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant FLT3 using Poly (Glu,Ala,Tyr) as substrate after 2 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
S*Bio

Curated by ChEMBL
LigandPNGBDBM50400312(CHEMBL2181330)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as decrease in formation of 4-hydroxytolbutamide from tolbutamide substrate after 60 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed