BDBM50400781 CHEMBL2204997

SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1

InChI Key InChIKey=WCKDYPHUXUBMEB-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50400781   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  79nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H2 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV39H1 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETMAR(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SETMAR using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of SET7 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT5 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  1.21E+5nMAssay Description:Inhibition of DNMT1 using polydi-dc as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 3 [N508S](Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of PRMT3 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PRMT1 using histone H4 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of G9a using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DOT1L using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3B(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of mouse DNMT3b1 using lambda DNA as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DNMT3a using lambda DNA as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400781(CHEMBL2204997)
Affinity DataIC50:  1.16E+5nMAssay Description:Inhibition of PRMT4 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed