BDBM50446139 CHEMBL3108882::US10730870, Example 135::US11512083, Example 135

SMILES Cc1cc(CC(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)on1

InChI Key InChIKey=FEFYMYQFVDBQAU-MJGOQNOKSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50446139   

Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50446139(CHEMBL3108882 | US10730870, Example 135 | US115120...)
Affinity DataKd:  1.50E+3nMAssay Description:Displacement of 19-mer HIF-1alpha peptide from VHL (unknown origin) by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVHL complex(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50446139(CHEMBL3108882 | US10730870, Example 135 | US115120...)
Affinity DataIC50:  1.92E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50446139(CHEMBL3108882 | US10730870, Example 135 | US115120...)
Affinity DataIC50:  1.92E+4nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In DepthDetails US Patent