BDBM50453799 Niguldipine

SMILES COC(=O)C1=C(C)NC(C)=C([C@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1

InChI Key InChIKey=SVJMLYUFVDMUHP-XIFFEERXSA-N

Data  16 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50453799   

TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  1.80nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  9nMAssay Description:Inhibition of [3H]nitrendipine binding to membrane homogenates of of rat cardiac muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  85nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  191nMAssay Description:Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  370nMAssay Description:Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi:  645nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50453799(Niguldipine)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed