BDBM50506546 Omidenepag::UR-7276

SMILES OC(=O)CNc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)n1

InChI Key InChIKey=YHGSTSNEOJUIRN-UHFFFAOYSA-N

Data  1 KI  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50506546   

TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to EP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 using 7-benzyloxyquinoline fluorescent substrate in presence of NADPH-generating system after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 using 3-cyano-7-ethoxycoumarin fluorescent substrate in presence of NADPH-generating system after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 using 7-methoxy-4-(trifluoromethyl)coumarin fluorescent substrate in presence of NADPH-generating system after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50:  5.48E+3nMAssay Description:Displacement of [3H]prostaglandin E2 from recombinant human full length EP4 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 using 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumariniodide fluorescent substrate in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 using 3-cyano-7-ethoxycoumarin fluorescent substrate in presence of NADPH-generating system after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]prostaglandin E2 from recombinant human full length EP3 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Ube Industries

Curated by ChEMBL
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]prostaglandin E2 from recombinant human full length EP1 receptor expressed in Chem-1 cell membranes after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))TBA
LigandPNGBDBM50506546(Omidenepag | UR-7276)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed