BDBM50509150 LY-3154207::Ly3154207::Mevidalen

SMILES C[C@@H]1N([C@@H](CO)Cc2c(CCC(C)(C)O)cccc12)C(=O)Cc1c(Cl)cccc1Cl

InChI Key InChIKey=XHCSBQBBGNQINS-DOTOQJQBSA-N

Data  1 IC50  7 EC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50509150   

TargetD(1A) dopamine receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  1.10nMAssay Description:Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTR...More data for this Ligand-Target Pair
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at human D5 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  3nMAssay Description:Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  5.50E+3nMAssay Description:Induction of CYP3A4 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  2.30nMAssay Description:Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Mus musculus (Mouse))
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  62nMAssay Description:Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataIC50:  3.80E+3nMAssay Description:Binding affinity to 5-HT1A receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair