BDBM50509558 CHEMBL4449356

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cccc(F)c23)c(F)c1

InChI Key InChIKey=PFVOSXMQCIFOSO-UHFFFAOYSA-N

Data  5 IC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50509558   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50:  3nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50:  34nMAssay Description:Allosteric inhibition of yeast GAL4 DNA domain-fused RORgammat LBD (97 to 518 residues) (unknown origin) expressed in HEK293T cells after 20 to 22 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human GAL4-fused RORgammat LBD transfected in Escherichia coli BL21(DE3) cell measured after 16 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50:  3.80nMAssay Description:Activity at biotinylated 6His-tagged human RORgamma LBD (259 to 518 residues) assessed as induction of biotinylated SRC1 peptide recruitment incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50509558(CHEMBL4449356)
Affinity DataIC50:  9.40nMAssay Description:Activity at RORgamma in human PBMC assessed as induction of IL17A production after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB