BDBM50519927 CHEMBL4546925

SMILES [H][C@]12C[C@@H]([C@H](CC)CN1CCc1c2[nH]c2cccc(OC)c12)C(=C/OC)\C(=O)OC

InChI Key InChIKey=LELBFTMXCIIKKX-MYLQJJOTSA-N

Data  9 KI  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50519927   

TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cells incubated for 120 mins by radiometric scintillation ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in HEK293 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  79nMAssay Description:Displacement of [125]IBNtxA from mouse MOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in rat RBL cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  329nMAssay Description:Binding affinity to KOP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  560nMAssay Description:Binding affinity to MOP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))TBA
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  649nMAssay Description:Displacement of [125]IBNtxA from mouse KOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi:  1.15E+3nMAssay Description:Displacement of [125]IBNtxA from mouse DOR stably expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to DOP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))TBA
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataEC50:  1.36E+3nMAssay Description:Agonist activity at mouse KOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 60 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataIC50:  1.09E+4nMAssay Description:Antagonist activity at mouse MOR expressed in CHO cell membranes assessed as inhibition of DAMGO induced [35S]-GTPgammaS binding incubated for 60 min...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)TBA
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataEC50:  73nMAssay Description:Partial agonist activity at mouse MOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 60 mins by sci...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of KOP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataIC50:  1.26E+4nMAssay Description:Antagonist activity at mouse DOR expressed in CHO cell membranes assessed as inhibition of DPDPE induced [35S]-GTPgammaS binding incubated for 60 min...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of MOP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human recombinant mu opioid receptor expressed in CHO cells assessed as stimulation of cAMP accumulation incubated for 10 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50519927(CHEMBL4546925)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of DOP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed