BDBM50532627 CHEMBL4514427

SMILES CNc1nccc(n1)N1CC[C@@H](C1)NC(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F

InChI Key InChIKey=GRRIIMXGYIQXDB-SFHVURJKSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532627   

TargetCyclin-C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532627(CHEMBL4514427)
Affinity DataIC50:  21nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532627(CHEMBL4514427)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532627(CHEMBL4514427)
Affinity DataIC50:  21nMAssay Description:Displacement of tracer236 from full-length His-tagged CDK8/cyclin C (unknown origin) incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50532627(CHEMBL4514427)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of CDK8 in IFN-gamma-induced human HCT116 cells assessed as suppression of STAT1 phosphorylation at serine727 residue incubated for 24 hrs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed