BDBM50543465 CHEMBL4636498
SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1ccc(OC)c(OC)c1
InChI Key InChIKey=UKYUETHIPBXYBQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50543465
Affinity DataEC50: 25nMAssay Description:Invivo antagonist activity at TLR9 in po dosed C57BL/6 mouse assessed as reduction of CpG-ODN-1585-induced IL-6 production pretreated for 30 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Antagonist activity at TLR7 in mouse whole blood cells assessed as inhibition of gardiquimod induced IL-6 production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Antagonist activity at TLR9 in mouse whole blood cells assessed as inhibition of ODN-2216 induced IL-6 production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Antagonist activity at TLR7 in human whole blood cells assessed as inhibition of gardiquimod induced IL-6 production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Antagonist activity at TLR8 in human whole blood cells assessed as inhibition of IL-6 production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Antagonist activity at TLR9 in human whole blood cells assessed as inhibition of ODN-2216 induced IL-6 production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at TLR7 in human pDC assessed as inhibition of inactivated flu-virus induced IFN-alpha production incubated for 24 hrs measured b...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Antagonist activity at TLR9 in human pDC assessed as inhibition of ODN2216-induced IFN-alpha production incubated for 24 hrs measured by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at TLR7 (unknown origin) in PBMC cells assessed as reduction of IL-6 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Antagonist activity at TLR9 (unknown origin) in PBMC cells assessed as reduction of IL-6 productionMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Agonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as NFkappaB expression by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Agonist activity at human TLR8 overexpressed in HEK293 cells assessed as NFkappaB expression by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Agonist activity at human TLR7 overexpressed in HEK293 cells assessed as NFkappaB expression by reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human TLR8 overexpressed in HEK-Blue cells assessed as inhibition of R848-induced NFkappaB and AP-1 activation preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.51E+4nMAssay Description:Antagonist activity at human TLR4 overexpressed in HEK-Blue cells assessed as inhibition of LPD-RK induced NFkappaB and AP-1 activation preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.44E+3nMAssay Description:Antagonist activity at human TLR3 overexpressed in HEK-Blue cells assessed as inhibition of Poly IC-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Invivo antagonist activity at TLR7 in po dosed C57BL/6 mouse assessed as reduction of gardiquimod-induced IL-6 production pretreated for 30 mins foll...More data for this Ligand-Target Pair